The Drug War has raged for over forty years. Yet, since 2006, the global War on Drugs has taken a turn for the truly awful. The Mexican Drug War has cost over 100,000 lives, it has destabilized not only Mexico, but also the entire Central American region (and, with Venezuela destabilizing on its own, the instability caused by drug cartels could spread there as things get more desperate). This piece assesses Mexico’s War on Drugs and how the U.S. can best respond to this instability.